منابع مشابه
Ketamine-induced QTc interval prolongation
Sir, Ketamine is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. It is widely used as a dissociative anesthetic and is also used as an adjunct in pain management, particularly in opioid-tolerant patients. It blocks calcium channels and depresses sodium channel function as well as having anticholinergic effects. It inhibits the re-uptake of the catecholamines and may hav...
متن کاملParoxetine‐induced QTc prolongation
There have been only two previous reports of paroxetine-induced corrected QT (QTc) prolongation on electrocardiogram (ECG). Here, we report a 43-year-old woman with QTc prolongation (476 ms). She had taken 50 mg of paroxetine for 17 days. Three days after discontinuation of paroxetine, QTc returned to within the normal limits (396 ms). Paroxetine blocks the human ether-a-go-go-related gene (HER...
متن کاملImpact of ABCB1 allelic variants on QTc interval prolongation.
PURPOSE Although the ABCB1 (P-glycoprotein) drug transporter is a constituent of several blood-tissue barriers (i.e., blood-brain and blood-nerve), its participation in a putative blood-heart barrier has been poorly explored. ABCB1 could decrease the intracardiac concentrations of drugs that cause QT prolongation and cardiotoxicity. EXPERIMENTAL DESIGN ABCB1-related romidepsin transport kinet...
متن کاملProlongation of the QTc interval in patients with cirrhosis
and in many congenital and acquired conditions as cardiac disease, electrolyte abnormalities, and many commonly used drugs. Additionally, acquired prolongation of QT interval has been documented in alcoholic liver disease, cirrhosis and liver failure. Liver transplantation in the latter group has been shown to reverse this anomaly. The QT prolongation was found to be independent of the etiology...
متن کاملFactors influencing QTc interval prolongation during kidney transplantation.
BACKGROUND During renal transplantation, factors causing disturbances of the repolarization process, defined by the QT interval, may lead to ventricular arrhythmias. The aim of this study was to determine a relationship between QT interval prolongation and metabolic homoeostasis, and durations of cold ischemia time (CIT) and warm ischemia time (WIT) during renal transplantation. MATERIAL/METH...
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ژورنال
عنوان ژورنال: Journal of Anaesthesiology Clinical Pharmacology
سال: 2017
ISSN: 0970-9185
DOI: 10.4103/0970-9185.173335